Voxyrel^®

Voxyrel® (Fluvoxamine) is a selective serotonin reuptake inhibitor (SSRI) that prevents neurons from reabsorbing serotonin while having minimal effect on norepinephrine or dopamine reuptake. It is mainly used to treat anxiety disorders, depression, and obsessive-compulsive disorder (OCD).

• Obsessive-compulsive disorder (OCD)
• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)
• Binge eating disorder
• Body dysmorphic disorder (BDD)
• Bulimia nervosa
• Panic disorder
• Post-traumatic stress disorder (PTSD)
• Social anxiety disorder (SAD)

Film-coated tablets: 50 mg and 100 mg

• Take exactly as prescribed by your doctor, with or without food.
• If taken once daily, it is recommended to take it before bedtime.
• Do not stop taking the medication abruptly without consulting your doctor.

If you forget a dose, take it as soon as you remember.

If it is near the time of the next dose, skip the missed dose.

Do not take two doses at the same time or an extra dose.

If you take more than the recommended dose, contact your doctor immediately.

Before starting and during treatment, the following may be monitored based on your doctor’s recommendation:

• Depression symptoms, worsening of symptoms, suicidal thoughts, or abnormal behavior changes (e.g., anxiety, irritability, panic attacks, insomnia, aggressive behavior, mania/hypomania, restlessness), especially during the first 1–2 months and during dose adjustments.
• Sodium levels in patients at risk of electrolyte disturbances.
• Blood glucose in diabetic patients and liver function tests.
• Weight and BMI in all patients.

• Known hypersensitivity to Fluvoxamine.
• Concomitant use or 14 days before and after discontinuation of monoamine oxidase inhibitor drugs
• Concomitant use with Linezolid or intravenous Methylene blue, Pimozide or Thioridazine

• Seek immediate medical attention if you experience fever, irregular heart rate, confusion, excessive sweating, irritability, tremor, muscle stiffness, or flushing.
• Fluvoxamine may cause drowsiness or dizziness; avoid activities requiring high alertness, such as driving or operating heavy machinery.
• Consult your doctor if you experience vision changes, eye pain, or swelling/redness around the eyes.
• Concurrent use with antiplatelet, anticoagulant, or NSAID medications may increase bleeding risk.
• Long-term use in elderly patients may increase the risk of bone fractures; extra caution is advised.
• Fluvoxamine may lower blood sodium, especially in older adults; this is reversible upon discontinuation. Report symptoms like headache, confusion, memory problems, or weakness.
• Use with caution in patients with uncontrolled epilepsy, as seizure risk may increase.
• Fluvoxamine should be tapered gradually and not stopped abruptly except in emergencies.
• The effectiveness of Fluvoxamine may be reduced in smokers.

• Consult your doctor before using Fluvoxamine during pregnancy or breastfeeding.
• Use during pregnancy and lactation should only be considered if the benefits outweigh the risks, under specialist supervision.

Possible side effects (not everyone experiences these):

• Loss of appetite, diarrhea, nausea, dry mouth
• Weakness, dizziness, drowsiness, headache, insomnia, irritability
• Changes in blood pressure, palpitations, syncope, excessive sweating, feeling hot or flushed
• Sexual dysfunction (more common in males)
• Weight changes

Consult your doctor or pharmacist before using Fluvoxamine with other medications or supplements (including herbal products).

Each package contains 30 tablets (3 blister packs of 10 tablets each).

• Store below 30°C, away from light and moisture.
• Keep out of reach of children and pets.
• Use before the expiration month on the package. Do not use expired medication.
• Keep in the original packaging until use.

1. Fluvoxamine: Drug Information, UpToDate 2024
2. Drugs.com Monograph
3. FDA Fluvoxamine Label