Telmitwin^®

Generic Name: Telmisartan and Amlodipine

Formulation: Film-coated, scored tablets of 40/5, 80/5, and 80/10 mg

Drug Class: Antihypertensive

Indications: This medication is used to control high blood pressure (hypertension).

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Telmitwin^®

Telmitwin^® contains two medications: Telmisartan and Amlodipine, and is prescribed for the control of high blood pressure.

• Telmisartan works by blocking the angiotensin II receptor, leading to the dilation of blood vessels.

• Amlodipine blocks calcium channels, which also affects blood vessels, leading to vasodilation.
  The combination of these two effects results in an effective reduction in blood pressure.

Indications for Telmitwin^®

Treatment of chronic high blood pressure in adults.

Dosage Form

Film-coated, scored tablets of 40/5, 80/5, and 80/10 mg.

Dosing and Administration

• Take Telmitwin^® as prescribed by your doctor. Do not stop taking the medication on your own.

• The use of Telmitwin^® requires careful and regular monitoring by your doctor at the beginning of the treatment, during the treatment period, and when discontinuing the medication.

• Take Telmitwin^® with a glass of water, consistently at the same time each day, with or without food.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at once or take an extra dose.

Overdose

If you take more than the recommended dose, contact your doctor or visit a healthcare facility immediately.

Monitoring During Treatment

• Blood pressure

• Serum electrolytes

• Renal function (creatinine and urea levels)

• Liver function

• Heart rate

• Peripheral edema

Contraindications for Telmitwin^®

• Allergy to Amlodipine or other dihydropyridine derivatives like Nifedipine, Telmisartan, or other ARBs (e.g., Valsartan, Losartan), or any components of the formulation.

• Concurrent use with Aliskiren in patients with diabetes or moderate to severe kidney impairment.

• Obstructive biliary disorders.

• Severe liver impairment.

• Shock (including cardiogenic shock).

• Severe hypotension (systolic blood pressure <90 mmHg).

• Severe obstruction or stenosis of left ventricular outflow arteries (e.g., severe aortic stenosis).

• Hemodynamically unstable heart failure after acute myocardial infarction.

• Pregnancy.

• Breastfeeding.

• Rare inherited disorder of fructose intolerance.

Warnings and Precautions for Telmitwin^®

• If you have a history of severe allergic reactions or experience symptoms like swelling, particularly of the face, lips, throat, or tongue after taking the medication, seek medical help immediately.

• Inform your doctor if you have a history of angina or heart attack.

• If you experience symptoms related to high potassium levels, such as irregular heartbeat, dizziness, weakness, lightheadedness, fainting, or shortness of breath, notify your doctor.

• There is a risk of low blood pressure in patients with reduced fluid volume (e.g., diarrhea, use of other diuretics, heart failure). Inform your doctor if any of these conditions occur.

• If you notice swelling in your hands, feet, or ankles after starting the medication, inform your doctor.

• Use with caution in patients with a history of heart, kidney, or liver issues. Your doctor should monitor you closely if you have any of these conditions.

• If you have significant aortic stenosis or mitral valve stenosis, inform your doctor.

• Telmisartan and Amlodipine should be used with caution in patients with ascites due to liver cirrhosis or refractory ascites. Regular monitoring of blood pressure and kidney function is recommended.

Pregnancy and Lactation

The use of Telmisartan and Amlodipine during pregnancy and breastfeeding is contraindicated.

Side Effects of Telmitwin^®

As with all medications, side effects may occur, though not all patients will experience them. Some possible side effects include:

• Dizziness

• Back pain

• Peripheral edema (swelling in the limbs)

Drug Interactions with Telmitwin^®

Consult your doctor or pharmacist before using Telmitoyin® with other medications or supplements.

Packaging

Each pack contains 30 tablets (3 blister packs of 10 tablets).

Storage Conditions for Telmitwin^®

• Store the medication at temperatures below 30°C, away from light and moisture.

• Do not use after the expiration date printed on the packaging.

• Keep the medication out of the reach of children.

• Do not remove the medication from its original packaging until ready to use.

References

1. Telmisartan and Amlodipine: Drug information, UpToDate 2025.