Levekin^®

Levekin® reduces the frequency of seizure attacks by modulating neurotransmitter activity and neuronal signal transmission pathways. Therefore, it is prescribed for the control and treatment of epilepsy.

• Various forms of epilepsy (partial and generalized seizures)
• Myoclonic epilepsy in patients aged 12 years and older
• Generalized tonic-clonic epilepsy in patients aged 6 years and older
• Prevention of seizures in conditions such as brain surgery, certain types of intracranial hemorrhage, and acute traumatic brain injury

Film-Coated Scored 250 mg, 500 mg, and 1000 mg Tablets

• Take Levekin® exactly as prescribed by your physician. Do not increase or decrease the dose or alter the duration of treatment without consulting your physician or pharmacist.
• Never discontinue Levekin® without consulting your healthcare provider.
• Take Levekin® at the same time(s) each day with a glass of water, either with food or on an empty stomach.

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time or an extra dose to make up for a missed dose.

If more than the prescribed dose is taken, contact your physician immediately or seek emergency medical attention.

Before and during treatment, your physician may periodically monitor:

• Complete blood count (CBC), particularly in patients with severe weakness, fever, recurrent infections, or coagulation abnormalities
• Liver function tests
• Suicidal ideation, depression, and behavioral changes

• Hypersensitivity to levetiracetam or any component of the formulation

• Abrupt discontinuation or rapid dose reduction of levetiracetam may lead to serious adverse effects and recurrent seizures. Therefore, treatment should be discontinued gradually under close medical supervision.
• Consult your physician if depression, anxiety, aggressive behavior, irritability, or mood and behavioral changes occur during treatment.
• Seek immediate medical attention if severe hypersensitivity reactions occur, including skin rash, swelling, blistering, skin peeling, eye redness, or ulceration of the mouth, throat, nose, or eyes.
• Inform your physician if you have kidney disease or a history of bariatric surgery.
• Levetiracetam may cause drowsiness or dizziness. Avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until you know how the medication affects you.

If treatment with levetiracetam is required during pregnancy or breastfeeding, consult your physician.

The use of levetiracetam during pregnancy and lactation should be based on specialist medical advice, taking into account the potential benefits and risks of treatment.

Like all medicines, Levekin® may cause side effects, although not everybody experiences them. Possible adverse reactions include:

• Weakness, balance disturbances, impaired coordination, dizziness, headache, and diplopia
• Behavioral changes including aggression, agitation, anxiety, apathy, confusion, depersonalization, depression, emotional instability, irritability, and hostile behavior
• Suicidal ideation, suspicious thoughts, and hallucinations
• Vomiting, diarrhea, decreased appetite, constipation, and abdominal pain
• Influenza-like symptoms
• Sinusitis, sore throat, and rhinorrhea

Consult your physician or pharmacist before taking levetiracetam concomitantly with any other medications or dietary supplements.

Each package contains 30 tablets (3 blister packs of 10 tablets each).

• Store below 30°C, protected from light and moisture.
• The product may be used until the last day of the month indicated as the expiration date on the package.
• Do not use or store expired medicines.
• Keep out of the reach of children.
• Do not remove the tablets from their original packaging until ready for use.

1. Levetiracetam: Drug information, UpToDate 2025
2. http://www.medicines.org.uk/emc/product/2291/smpc