Talajade®
Patient Details
Generic Name: Deferasirox
Dosage Form: Film-coated, scored tablet 360 mg
Drug Category: Iron chelating agent
Indications: Treatment of chronic iron overload in patients with thalassemia.
Talajade®
Talajade® (deferasirox) is an iron chelator. By binding iron and eliminating it via the stool, it reduces serum iron levels and the risk of iron deposition in organs.
Indications for Talajade®
· Treatment of chronic iron overload in transfusion-dependent thalassemia.
· Treatment of chronic iron overload in non–transfusion-dependent thalassemia.
Dosage Form of Talajade®
Film-coated, scored tablet 360 mg.
Dose and Administration of Talajade®
Take Talajade® exactly as prescribed. To achieve the best response, do not increase or decrease the dose or duration without consulting your doctor.
Take with a glass of water on an empty stomach or after a light, low-fat meal (about 250 kcal).
Avoid taking Talajade® at the same time as aluminum-containing antacids.
Missed Dose
Take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose. Do not take two doses at once or extra doses.
Overdose
If you take Talajade® more than recommended, contact your doctor or go to a medical center immediately.
Known symptoms of overdose include
· Abdominal pain, diarrhea, nausea, vomiting
· Liver and kidney problems
· Monitoring while on Talajade®
· Serum iron, ferritin, and TIBC
· Complete blood count (CBC)
· Kidney and liver function
· Vision and hearing status
· Serum electrolytes
· Urinalysis
· Blood glucose in diabetic patients
· Appearance of skin lesions (e.g., red patches)
· Development of peptic ulcer or GI bleeding
Contraindications for Talajade®
· Hypersensitivity to deferasirox or any component of the formulation
· Severe renal or hepatic failure
· Advanced malignancies
· Platelet count < 50,000/µL
· Creatinine clearance < 60 mL/min
Warnings and Precautions for Talajade® Use
· If you experience hypersensitivity reactions (rash, difficulty breathing or swallowing, swelling of lips, face, throat, or tongue), seek urgent care.
· If you develop hearing or vision problems, severe skin reactions (red patches, erythema, blisters of lips/mouth, skin peeling, enlarged lymph nodes), hematemesis, black stools, or severe abdominal pain, stop deferasirox and seek medical attention immediately.
· If you develop signs of liver dysfunction (drowsiness, vomiting, right-upper-quadrant pain, jaundice, dark urine), seek care immediately.
· If you develop signs of kidney dysfunction (inability to urinate, changes in urine output, blood in urine, excessive weight gain), inform your doctor immediately.
· Use with extra caution in the elderly.
Talajade® Use During pregnancy and lactation
Use during pregnancy is not recommended unless clearly necessary and as judged by the physician.
Deferasirox may reduce the effectiveness of oral contraceptives; use an additional physical method (e.g., condom).
Use during breastfeeding is not recommended.
Side effects of Talajade®
As with all medicines, side effects may occur (not everyone is affected). Possible reactions include:
· Diarrhea
· Abdominal pain
· Nausea and vomiting
· Constipation
· Fatigue, dizziness, headache, anxiety, insomnia
· Fever
· Sore throat and cough
Packaging of Talajade®
Each bottle contains 30 tablets.
Storage Conditions for Talajade®
· Store below 30°C, protected from light and moisture.
· Usable until the end of the month shown in the expiry date. Do not use or keep out-of-date medicines.
· Keep out of the sight and reach of children.
· Do not remove from the original package until use.
References
1. Deferasirox: Drug information, UpToDate 2025
2. http://www.medicines.org.uk/emc/product/15751/smpc
