Rofend inj^®

Rofend®

Generic Name: Voriconazole
Dosage Form: 200 mg lyophilized powder for solution for injection
Drug Class: Antifungal

Indications for Rofend®:

Rofend® is used to treat various fungal infections, including:

• Skin infections
• Respiratory infections
• Kidney infections
• Abdominal infections
• Blood infections

How Rofend® Works:

Rofend® (Voriconazole) is a broad-spectrum antifungal from the triazole class. It reduces the synthesis of ergosterol, a vital component of fungal cell membranes, inhibiting the formation of the fungal membrane and ultimately leading to the death of the fungus.

Indications for Rofend® Use:

• Treatment of infections caused by fungi such as Aspergillus, Blastomyces, and others.
• Treatment of Candida infections, including disseminated skin and abdominal infections, bloodstream infections, cardiac involvement, esophageal candidiasis, and ocular candidiasis.
• Treatment of severe fungal infections caused by Scedosporium and Fusarium species in patients who cannot use other antifungal drugs or are resistant to them.
• Prevention of invasive fungal infections.

Dosage Form of Rofend®:

• 200 mg lyophilized powder for solution for injection.

Preparation of Rofend®:

• Add 19 mL of sterile water for injection to the vial of Rofend® and allow the powder to dissolve completely. Each mL of the resulting solution contains 10 mg of Voriconazole.
• Never inject the solution before dilution. The prepared solution must be diluted to a concentration of 0.5 to 5 mg/mL in compatible solvents.

The solution can be diluted with the following solutions:

• 0.9% or 0.45% Sodium Chloride
• Ringer's Lactate
• 5% Dextrose in Ringer's Lactate
• 5% Dextrose and 0.45% or 0.9% Sodium Chloride
• 5% Dextrose

How to Administer Rofend®:

• Rofend® is for intravenous infusion only; avoid intravenous bolus injection.
• The final solution should be infused over 1 to 2 hours, at a maximum rate of 3 mg/kg/hour.
• This product is for single use only. Discard any remaining medication after use.

Monitoring During Rofend® Treatment:

• Serum electrolyte levels, especially potassium, magnesium, and calcium, should be corrected before administration and monitored during treatment.
• Kidney function (especially serum creatinine) and liver function should be monitored before and during treatment with Rofend®.
• Pancreatic function.
• Full-body skin examination.
• Blood drug concentration may need to be monitored just before administering the next dose.
• Visual status (especially visual fields and color perception) for treatments longer than 28 days.
• Photosensitivity, especially in children.

Contraindications for Rofend®:

• Allergy to Voriconazole or any component of the formulation.
• Simultaneous use with drugs such as:
• Long-acting barbiturates, Alprazolam, Amiodarone, Aprepitant, Doxorubicin, Domperidone, Carbamazepine, Cisapride, Efavirenz, Ritonavir, Ergotamine, Ivabradine, Lorazidone, Pimozide, Quinidine, Rifampin, Rifabutin, Ritonavir, Sirolimus, St. John's Wort, Tolvaptan, Phenobarbital, Lovastatin, Midazolam, Simvastatin, Triazolam

Warnings and Precautions for Rofend®:

• The combination of Rofend® with corticosteroids (like prednisone and dexamethasone) may increase the risk of Cushing's syndrome. If you experience symptoms such as unusual weight gain, fat accumulation on the sides of the face or neck, thinning skin, excessive sweating, or easy bruising, contact your doctor immediately.
• Patients should avoid exposure to direct sunlight during treatment and wear protective clothing and high-SPF sunscreen.
• Electrolyte imbalances (such as low calcium, magnesium, or potassium) should be corrected before and during treatment.
• This drug should be used with caution in patients with liver and kidney dysfunction, and dosage adjustments may be needed.
• Seek immediate medical attention if you experience widespread allergic reactions such as redness, swelling, blisters, or peeling skin, eye redness, mouth sores, fever, chills, or shortness of breath.
• Use caution in patients with structural heart disease or QT syndrome. Contact your doctor if you experience rapid or abnormal heartbeats or fainting.
• Contact your doctor if you experience bone pain or vision changes.
• Voriconazole has nonlinear pharmacokinetics, so patients should be monitored for signs of toxicity.

Rofend® Use During Pregnancy and Breastfeeding:

• The use of Rofend® during pregnancy and breastfeeding is not recommended.
• If you are planning to become pregnant, consult your doctor before using this medication.

Side Effects of Rofend®:

Like all medications, Rofend® may cause side effects, although not everyone will experience them. Some common potential side effects include:

• Headache or dizziness
• Nausea, vomiting, constipation, diarrhea, and abdominal pain
• Cold-like symptoms
• Skin reactions
• Increased liver enzyme levels
• Acute kidney injury
• Cardiovascular effects
• Ocular and neurological side effects

Drug Interactions with Rofend®:

• Consult your doctor or pharmacist before using Voriconazole with any other medications or supplements.

Packaging of Rofend®:

• Each package contains 1 vial of Rofend®.

Storage Conditions for Rofend®:

• Store the medication at temperatures below 30°C, away from light and moisture.
• The drug can be used until the expiration date on the packaging. Do not use or store expired medications.
• Keep out of reach of children.
• Do not remove the medication from its original packaging until use.

References:

1. Voriconazole: Drug information, UpToDate 2025
2. Medicines.org.uk - Product Information