Pepticare inj^®

Pepticare®

Generic Name: Pantoprazole
Formulation: Lyophilized powder containing 40 mg of pantoprazole for injectable solution
Pharmacological Class: Proton Pump Inhibitor (PPI)

Indications for Pepticare®:

Pepticare® is used in the treatment of Gastroesophageal Reflux Disease (GERD) and other related conditions.

Indications:

• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome
• Prevention of aspiration of gastric contents during anesthesia
• Prevention and treatment of gastric ulcers
• Prevention of stress-induced gastric ulcers
• Acute upper gastrointestinal bleeding
• Prevention of excessive gastric acid secretion due to pancreatic or duodenal tumors (Zollinger-Ellison syndrome)

Pepticare® Composition:

Lyophilized powder containing 40 mg pantoprazole for preparing an injectable solution.

Preparation of Pepticare®:

Pepticare® is compatible with the following solutions:

• 0.9% Sodium Chloride
• 5% Dextrose
• Ringer's Lactate

Preparation Instructions:

1. To prepare the solution, add 0.9% Sodium Chloride to the vial, dissolving the powder.
2. Once dissolved, dilute the solution for intravenous infusion using one of the compatible solutions mentioned above.
3. The final solution should be clear, free of particles, and colorless.

Before and after the injection, the IV line should be flushed with 5% Dextrose or Normal Saline.

Administration and Dosage of Pepticare®:

• Pepticare® should only be administered slowly via intravenous injection or infusion.
• IV injection should be administered at a concentration of 4 mg/mL over at least 2 minutes.
• Diluted solution can be infused intravenously over 15 minutes.
• Each vial of Pepticare® is for single use only; any remaining solution should be discarded.

Monitoring During Pepticare® Treatment:

• Magnesium levels: Monitor before starting and periodically during treatment, especially in patients on digoxin, diuretics, or other medications that can cause hypomagnesemia.
• Bone loss and fractures
• Clostridium difficile-related diarrhea
• Calcium and gastrin levels
• Gastric acid secretion levels in patients with excessive acid secretion
• Signs or symptoms of cutaneous lupus erythematosus or systemic lupus erythematosus.

• ---

Contraindications:

• Hypersensitivity to pantoprazole or any components of the formulation
• History of hypersensitivity to other proton pump inhibitors (e.g., omeprazole, lansoprazole, rabeprazole, esomeprazole)
•  In combination with rilpivirine-containing products

Warnings and Precautions for Pepticare®:

• Consult a doctor immediately if you experience any of the following symptoms: unexplained weight loss, difficulty swallowing, stomach pain, dyspepsia, vomiting or vomiting blood, black or bloody stools, or persistent diarrhea.
• Severe allergic reactions: Redness, swelling, rash, blisters, hives, itching, wheezing, tightness in the chest or throat, difficulty breathing, swallowing, or speaking, and unusual hoarseness. Seek immediate medical help.
• Long-term use (over 1 year): May increase the risk of bone fractures, particularly in the elderly, children, people with osteoporosis, and those on high doses.
• Lupus symptoms: Be alert for signs of cutaneous or systemic lupus erythematosus.
• Vitamin B12 deficiency: Long-term use may reduce absorption. If you experience muscle weakness, fatigue, paleness, mood changes, or tingling in limbs, consult your doctor.
• Clostridium difficile diarrhea: Proton pump inhibitors like pantoprazole can increase the risk of C. difficile infection, causing symptoms like stomach pain, watery or bloody diarrhea. Contact your doctor immediately if such symptoms occur.
• Effect on laboratory tests: May interfere with tests such as chromogranin A levels.
• Drug interaction with Clopidogrel: Pepticare® may reduce the effectiveness of clopidogrel.

Use of Pepticare® During Pregnancy and Breastfeeding:

• Pregnancy: Consult your doctor or pharmacist before using Pepticare® during pregnancy.
• Breastfeeding: The use of Pepticare® during breastfeeding should be weighed against potential risks and benefits.

Side Effects of Pepticare®:

Like all medications, Pepticare® may cause side effects, though not everyone will experience them. Possible side effects include:

• Headache or dizziness
• Hypersensitivity reactions
• Joint pain
• Gastrointestinal infections (intestinal infections)

Drug Interactions with Pepticare®:

Always inform your doctor or pharmacist about all medications (prescription, over-the-counter, or herbal supplements) you are currently taking before using Pepticare®.

Pepticare® Packaging:

Each package contains 10 vials.

Storage Conditions for Pepticare®:

• Store unopened vials at below 25°C, away from light and freezing.
• Use before the expiration date stated on the package.
• Keep out of reach of children.

References:

1. Pantoprazole: Drug Information, UpToDate, 2025
2. Medicines.org.uk – Pepticare® Product Information