Levekin ER^®

Levekin® ER reduces the frequency of seizure attacks by modulating neurotransmitter activity and neuronal signal transmission pathways. Therefore, it is prescribed for the control and treatment of epilepsy.

Focal (Partial-Onset) Seizures in adults and adolescents 12 years of age and older.

500 mg and 750 mg Extended-Release Scored Film-Coated Tablets

Take this medication exactly as prescribed by your physician. Do not increase or decrease the dose, or alter the duration of treatment, without consulting your physician or pharmacist.

Never discontinue Levekin® ER without informing your healthcare provider. Abrupt discontinuation or dose reduction may lead to serious adverse effects and recurrent seizure attacks; therefore, treatment should be withdrawn gradually under close medical supervision.

Take Levekin® ER with a glass of water, with or without food.

Do not chew, crush, or split the tablets.

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time or an extra dose to make up for a missed dose.

In case of accidental overdose or if more than the prescribed amount is taken, contact your physician or pharmacist immediately.

• Complete Blood Count (CBC) in patients presenting with severe weakness, fever, recurrent infections, or coagulation abnormalities.
• Monitoring for suicidal ideation, depression, and behavioral changes.

• History of severe hypersensitivity to levetiracetam or any component of the formulation.

• Levetiracetam may cause central nervous system depression, resulting in symptoms such as fatigue, dizziness, and somnolence, which may impair physical or mental performance. These effects are most commonly observed during the first month of treatment and following dose escalation.
• Activities requiring mental alertness, such as driving or operating heavy machinery, should be performed with caution.
• Seek immediate medical attention if severe hypersensitivity reactions occur, including widespread rash, swelling, blistering, skin peeling, redness of the eyes, or sores in the mouth, throat, nose, or eyes.
• Levekin® ER should be used with caution in patients with renal impairment, and dosage adjustment may be required.
• Following bariatric surgery, the efficacy and safety of the medication should be reassessed.
• Consult your physician if you experience depression, anxiety, aggressive behavior, irritability, nervousness, or other mood and behavioral changes.

• If you are pregnant, breastfeeding, or planning to become pregnant, consult your physician or pharmacist before taking Levekin® ER.
• If treatment is continued during pregnancy, patients should be carefully monitored throughout pregnancy and the postpartum period.
• The decision to breastfeed during treatment should consider the potential risk of infant exposure to the drug, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother.

Like all medicines, Levekin® ER may cause side effects in addition to its therapeutic benefits, although not everybody experiences them. Possible adverse reactions include:

• Diarrhea, stomach pain or discomfort, or decreased appetite
• Dizziness, drowsiness, fatigue, or weakness
• Sleep disturbances
• Headache

Consult your physician or pharmacist before taking Levekin® ER concomitantly with any other medications or dietary supplements.

Each bottle contains 60 tablets.

• Store below 30°C, protected from light and moisture.
• The product may be used until the last day of the month indicated as the expiration date on the package.
• Do not use or keep expired medicines.
• Keep out of the reach of children.
• Do not remove the medication from its original packaging until it is ready to be used.

1. Levetiracetam: Drug information, UpToDate 2025
2. https://www.drugs.com/pro/elepsia-xr.html